Treatment of Hypercholesterolemia
نویسندگان
چکیده
منابع مشابه
Familial Hypercholesterolemia: From Diagnosis to Treatment
Familial hypercholesterolemia (FH) is an inherited common autosomal Mendelian disorder of lipoprotein metabolism with a population prevalence of 1 in 500. FH is characterized by severely elevated levels of low-density lipoprotein cholesterol (LDL-C), which result in surplus deposition of cholesterol in tissues. This condition leads to premature at hero sclerosis and early-onset of coronary hear...
متن کاملTreatment of Hypercholesterolemia
Numerous randomized, double blind, placebo-controlled studies and observational studies have shown that statins reduce mortality and major cardiovascular events in high-risk patients with hypercholesterolemia. The Heart Protection Study showed that statins reduced mortality and major cardiovascular events in high-risk patients regardless of the initial level of serum lipids, age, or gender. The...
متن کامل[Diagnosis and treatment of familial hypercholesterolemia].
Familial hypercholesterolemia is the most frequent monogenetic disease. The mode of transmission is autosomal dominant. This disease is characterized by severe elevations of low-density lipoprotein cholesterol (LDLc), with the possibility of deposits in different tissues. Unless treated appropriately, this disorder carries a high risk of vascular complications and shortened life expectancy. The...
متن کاملPCSK9 Antibodies for the Treatment of Hypercholesterolemia
The serine protease proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein (LDL) receptor (LDLR) and directs it to lysosomes for intracellular degradation. This results in decreased numbers of LDLR available on the hepatic cell surface to bind LDL particles and remove them from the circulation and therefore to a subsequent increase in circulating LDL-choleste...
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ژورنال
عنوان ژورنال: Journal of Clinical & Experimental Cardiology
سال: 2013
ISSN: 2155-9880
DOI: 10.4172/2155-9880.s1-006